Title : Current and future pharmacological therapies for managing cirrhosis and its complications
link : Current and future pharmacological therapies for managing cirrhosis and its complications
Current and future pharmacological therapies for managing cirrhosis and its complications
World J Gastroenterol. Feb 28, 2019; 25(8): 888-908Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.888
Current and future pharmacological therapies for managing cirrhosis and its complications
David Kockerling, Rooshi Nathwani, Roberta Forlano, Pinelopi Manousou, Benjamin H Mullish, Ameet Dhar
Core tip: Pharmacological therapy is central to the management of cirrhosis and its complications. Whilst there has been recent debate about the safety of beta-blockade in patients with ascites, conversely there is growing interest in potential benefits relating to a reduction in gut bacterial translocation and hepatocellular carcinoma risk. In addition to its well-established role in treating hepatic encephalopathy, rifaximin may also have a key role in preventing secondary infections. In this review, we summarise these and other uncertainties, controversies and novel developments related to pharmacotherapy in the clinical management of chronic liver disease.
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