Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older - Hallo friendsTHE LEK NEWS, In the article you read this time with the title Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article culture, Article economy, Article health, Article healthy tips, Article news, Article politics, Article sports, We write this you can understand. Alright, good read.

Title : Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older
link : Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older

Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older

Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older

Graham R. Foster , Tarik Asselah, Sarah Kopecky-Bromberg, Yang Lei, Armen Asatryan, Roger Trinh, Neddie Zadeikis, Federico J. Mensa

Full-text article

View Online

Download PDF

Abstract
Finding safe and effective treatments for chronic hepatitis C virus (HCV) infection in the elderly is of clinical interest given the comorbidities and associated polypharmacy in this population. However, the number of patients older than age 65 years enrolled into clinical trials of anti-HCV medications generally have been limited and thus reaching meaningful conclusions for this demographic has been difficult. Glecaprevir/pibrentasvir is a once-daily, all-oral, ribavirin-free, pangenotypic direct-acting antiviral (DAA) combination therapy that has demonstrated high sustained virologic response rates at post-treatment week 12 (SVR12) and a favorable safety profile in patients with chronic HCV infection. This analysis evaluated the safety and efficacy of glecaprevir/pibrentasvir in patients aged ≥65 years. Data were pooled for treatment-naïve and -experienced patients with chronic HCV genotype (GT) 1–6 infections who received glecaprevir/pibrentasvir for 8, 12, or 16 weeks in 9 Phase 2 and 3 trials. SVR12 and adverse events (AEs) were evaluated for patients aged ≥65 versus <65 years. Of the 2369 patients enrolled, 328 (14%) were aged ≥65 years. Among patients aged ≥65 years, 42% and 34% had GT1 and GT2, respectively; 40% were treatment-experienced and 20% had compensated cirrhosis. Glecaprevir/pibrentasvir treatment resulted in SVR12 rates of 97.9% (95% CI, 96.3–99.4; n/N = 321/328) for patients aged ≥65 years and 97.3% (95% CI, 96.6–98.0; n/N = 1986/2041) for patients aged <65 years. The rates were not significantly different between the two age groups (P = 0.555). DAA-related AEs leading to treatment discontinuation, or serious AEs were similarly rare (<0.5%) for patients ≥65 and <65 years old. Glecaprevir/pibrentasvir is an efficacious and well-tolerated treatment option for patients aged ≥65 years with chronic HCV infection.
Full article: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208506 

Thus Article Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older

That's an article Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older This time, hopefully can give benefits to all of you. well, see you in posting other articles.

You are now reading the article Hepatitis C: Mavyret (glecaprevir/pibrentasvir) in patients aged 65 years or older with the link address https://theleknews.blogspot.com/2019/01/hepatitis-c-mavyret-glecaprevirpibrenta.html

Tweet

Subscribe to receive free email updates: