HCV patients treated with DAA undergo a marked reduction of insulin resistance - Hallo friendsTHE LEK NEWS, In the article you read this time with the title HCV patients treated with DAA undergo a marked reduction of insulin resistance, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article culture, Article economy, Article health, Article healthy tips, Article news, Article politics, Article sports, We write this you can understand. Alright, good read.

Title : HCV patients treated with DAA undergo a marked reduction of insulin resistance
link : HCV patients treated with DAA undergo a marked reduction of insulin resistance

HCV patients treated with DAA undergo a marked reduction of insulin resistance

Improvement of insulin sensitivity in diabetic and non diabetic patients with chronic hepatitis C treated with direct antiviral agents 
Alessandro Gualerzi, Mattia Bellan , Carlo Smirne, Margherita Tran Minh, Cristina Rigamonti, Michela Emma Burlone, Ramona Bonometti, Sara Bianco, Azzurra Re, Serena Favretto, Giorgio Bellomo, Rosalba Minisini, Gian Piero Carnevale Schianca, Mario Pirisi
Published: December 20, 2018 https://doi.org/10.1371/journal.pone.0209216 

Full-Text Article

Download PDF

View Online

Abstract

Background
The increased incidence of type 2 diabetes mellitus among hepatitis C virus (HCV) infected patients is likely due to viral-induced insulin resistance (IR). Indeed, control of diabetes in these patients benefits of successful antiviral treatment; whether the same applies to subtler alterations of glucose metabolism is unknown. We aimed to fill this gap.

Methods
The study population included 82 HCV-RNA positive patients (48 males, median age 66 years, 73 with advanced fibrosis, 41 HCV-1b), attending the liver clinic of an academic hospital to receive direct antivirals. None was previously known to be diabetic. All underwent a standard oral glucose tolerance test (OGTT) before antiviral treatment and right after its conclusion.

Results
At baseline, the majority of patients had evidence of abnormal glucose metabolism (N. = 45, 55%; impaired fasting glucose 10%, impaired glucose tolerance16%, both the above 12%, 17% diabetes), while only 37 (45%) were normally glucose tolerant (NGT). At the end of treatment, HCV-RNA quantification was below the detection threshold (HCV-RNA <12 UI/ml), for all patients enrolled. A significant decrease in glucose and insulin plasma concentrations was observed, leading to a significant reduction in Homeostasis Model Assessment (HOMA)-IR (from 3.42 [2.66–5.38] to 2.80 [1.78–3.95];p<0.001) and a corresponding increase in insulin sensitivity (ISI Belfiore from 0.49 [0.26–0.75] to 0.64 [0.42–0.91];p<0.001), despite a significant reduction in insulin secretion (EFP Stumvoll from 1363 [959–1730] to 1264 [976–1588];p = 0.027). Importantly, HOMA-IR reduction occurred also in the subgroup of NGT patients (p = 0.017). The number of NGT patients increased to 53, 65% (p = 0.013) paralleled by a reduced number of those satisfying criteria for prediabetic conditions (31 (38%) vs. 17 (21%); p = 0.025).

Conclusions

Glucose metabolism parameters of HCV infected patients improve early after antiviral treatment, with benefits that are not limited to diabetics. These findings confirm how deep and widespread is the impairment of insulin pathways exerted by HCV infection.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209216

Thus Article HCV patients treated with DAA undergo a marked reduction of insulin resistance

That's an article HCV patients treated with DAA undergo a marked reduction of insulin resistance This time, hopefully can give benefits to all of you. well, see you in posting other articles.

You are now reading the article HCV patients treated with DAA undergo a marked reduction of insulin resistance with the link address https://theleknews.blogspot.com/2018/12/hcv-patients-treated-with-daa-undergo.html

Tweet

Subscribe to receive free email updates: