Title : Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
link : Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
Medicine: March 2018 - Volume 97 - Issue 10 - p e9782Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
Huang, Ching-I MDa,b; Huang, Chung-Feng MDa,b,c; Yeh, Ming-Lun MDb,c; Lin, Yi-Hung MDb,d; Liang, Po-Cheng MDb,d; Liu, Shang-Yin Vanson PhDe; Hsieh, Meng-Hsuan MDb,c,f; Lin, Zu-Yau MD, PhDb,c; Chen, Shinn-Cherng MD, PhDb,c; Huang, Jee-Fu MD, PhDa,b,c; Chuang, Wan-Long MD, PhDa,b,c; Dai, Chia-Yen MD, PhDa,b,c,f,*; Yu, Ming-Lung MD, PhDa,b,c,*
Full Text
https://journals.lww.com/md-journal/fulltext/2018/03090/Role_of_IL_28B_genetic_variants_in_HCV_related.41.aspx
Abstract
Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results. The impact of IL-28B in Asian patients with different viral genotypes remains elusive. We try to elucidate the effect of IL-28B genetic variants in a large Asian cohort with different viral genotypes.
The association between the IL-28B rs8099917 genotype and liver fibrosis was investigated in 1288 patients with biopsy-proven CHC. Patients with hepatitis C virus genotype 1 (HCV-1) infection comprised 59.4% of the population. The remaining 40.6% (518 patients) did not have HCV-1 infection. Of the 1084 patients with the IL-28 genotype, 85.6% (928 patients) had the TT genotype. Univariate analysis revealed that, compared to patients without advanced liver fibrosis, patients with advanced liver fibrosis (Metavir fibrosis score 3-4) had an older age, a lower platelet count, a higher α-fetoprotein level, a higher alanine aminotransferase level, a higher incidence of diabetes, and a higher frequency of rs8099917 non-TT genotype carriage.
Logistic regression analysis revealed that factors significantly associated with advanced liver fibrosis included age (odds ratio [OR]/95% confidence interval [CI]: 1.023/1.009-1.037, P = .001), diabetes (OR/CI: 1.736/1.187-2.539, P = .004), α-fetoprotein (OR/CI: 1.007/1.002-1.012, P = .009), platelet count (OR/CI: 0.991/0.988-0.993, P < .001), and carriage of the rs8099917 non-TT genotype (OR/CI: 0.585/0.400-0.856, P = .006).
When patients were classified by viral genotype, factors that had significant independent associations with advanced liver fibrosis in patients with HCV-1 infection included diabetes (OR/CI: 2.379/1.452-3.896, P = .001), α-fetoprotein (OR/CI: 1.023/1.012-1.035, P < .001), platelet count (OR/CI: 0.99/0.987-0.994, P < .001), and carriage of the rs8099917 non-TT genotype (OR/CI: 0.529/0.328-0.854, P = .009).
In patients who had advanced liver fibrosis but not HCV-1 infection, factors that had significant independent associations with advanced liver fibrosis included age (OR/CI: 1.039/1.016-1.063, P = .001) and platelet count (OR/CI: 0.99/0.986-0.995, P < .001); additionally, IL-28B genetic variants were not associated with liver disease severity.
Unfavorable IL-28B genetic variants were associated with advanced liver disease. The genetic effect is limited to patients with HCV-1 infection.
Thus Article Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes
That's an article Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes This time, hopefully can give benefits to all of you. well, see you in posting other articles.
You are now reading the article Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes with the link address https://theleknews.blogspot.com/2018/03/role-of-il-28b-genetic-variants-in-hcv.html
0 Response to "Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes"
Post a Comment