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Title : December 2017 - Viral hepatitis newsletter and blog updates
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December 2017 - Viral hepatitis newsletter and blog updates

Welcome folks, check out recent journal and blog updates along with this months viral hepatitis newsletters.

In The News

Hepatitis A Outbreak in California
December 6, 2017 | M. Kushel
(DOI: 10.1056/NEJMp1714134)
Most people affected by California’s hepatitis A outbreak are homeless, and infectious diseases are one of many health threats they face. To address the root cause of their health problems, we will need sustained efforts to fix the housing-affordability crisis.

Healio

HCV nucleic acid test offers ‘opportunity’ to increase liver transplant pool

“Now that we have [nucleic acid testing (NAT)] available, that should be considered in labeling the donors rather than hepatitis C-positive or not,” Khurram Bari, MD, from the University of Cincinnati, told Healio Gastroenterology and Liver Disease. “NAT testing is a better indicator of hepatitis C positivity or negativity in donors ...

Resistance analysis of Epclusa shows patients may retreat with sofosbuvir

December 6, 2017

Treatment with Epclusa for 12 weeks resulted in high sustained virologic response rates among patients with hepatitis C genotypes 1 through 6, irrespective of baseline…

Growth in retail drug spending freefalls along with hepatitis C drug costs, analysis says

by Eric Sagonowsky
Dec 6, 2017 

Drug pricing has been under a microscope in recent years as policymakers, market watchers and others look to determine what's sending costs upward. But a new report says retail spending on pharmaceuticals grew at a much slower rate last year than in recent history.

Journal Updates

Alimentary Pharmacology & Therapeutics

Interferon-free therapy of chronic hepatitis C with direct-acting antivirals does not change the short-term risk for de novo hepatocellular carcinoma in patients with liver cirrhosis
F. Mettke, B. Schlevogt, K. Deterding, A. Wranke, A. Smith, K. Port, M. P. Manns, A. Vogel, M. Cornberg, H. Wedemeyer
First published: 4 December 2017
Full publication history DOI: 10.1111/apt.14427
AIM: To investigate the HCC incidence in cirrhotic HCV patients who cleared HCV with direct-acting antivirals vs untreated controls.

On Twitter

The following article was shared on Twitter, by @HenryEChang

The effect of IFN-free regimens on health-related quality of life in East Asian patients with chronic HCV

In this study, we assessed quality of life in East Asian HCV patients who underwent treatment with an interferon-free regimen containing sofosbuvir+ribavirin, and found superior on-treatment quality of life scores of these patients during treatment and after achieving SVR.

Clinical Care Options
HBV Treatment at AASLD 2017: My Take on New Data
Tram T. Tran, MD

At AASLD 2017 in Washington, DC, the rapid advancement of research in HBV treatment was on full display. Exciting new data were presented on both current and investigational therapies. Here, I have highlighted some of the abstracts I found most interesting.
*free registration required

Blog Updates

HEPATITISC.NET
Living with Pain and Hep C in an “Opioid Crisis” Era
By Daryl Luster - December 5, 2017
Living with any pain, whether acute (shorter duration) or chronic (ongoing). In medical terms, these are two terms that are used outside of the strictest definition of their meaning. Having a broken...

Hepatitis C – Buddy or Bozo?
By Carleen Mcguffey - December 4, 2017
I had been married to my husband, James, for 7 years before we had children, mostly due to the influence of the world around me, and also partly because of selfishness. I...

The Holiday Season with Hepatitis C spotlight
By Editorial Team - December 1, 2017
Tis the season! The holidays can be a time of celebration, but the holidays can add an additional amount of stress for anyone managing hepatitis C and liver disease.

Hepatitis B Foundation

HIV/HBV Co-Infection
December 6, 2017 World AIDS Day was last Friday, December 1st. It is a day dedicated to raising awareness about HIV and AIDS. However, it is also a great opportunity to discuss the possibility of coinfection with hepatitis B virus, HBV.

Special Film Screening: “Hilleman: A Perilous Quest to Save the World’s Children”

The documentary film, produced by The Vaccine Makers Project, follows the unknown story of a man who “had more of an impact on [people’s] lives compared to Einstein.” The film tells the story of a courageous and gutsy scientist, Dr. Maurice R. Hilleman, and the elimination of diseases of children. With his unwavering determination, Dr. Hilleman invented the first-ever vaccine against a human cancer (the hepatitis B vaccine), developed the measles-mumps-rubella (MMR) combination vaccine, and prevented pandemic flu. During World War II he developed an urgently needed vaccine for Japanese B encephalitis in 30 days.

HEP - Blog Updates

How Hepatitis C Damages Your Health

December 7, 2017
By Greg Jefferys
A closer look at how HCV damages the body.

Can’t Sleep with Liver Disease 

December 6, 2017

By Karen Hoyt
Advanced liver disease can create problems with your dream time.

Crime and Double Punishment 
December 4, 2017

By NVHR Staff
NMDC policy fails to list another potential penalty for a major offense: denial of lifesaving treatment for the deadly hepatitis C virus.

Hepatitis C: Not Gone and at Risk of Being Forgotten 

December 4, 2017

By Lucinda K. Porter, RN
Hepatitis C is curable, but it is not gone. Not by a long shot.

Seasonal Flu

HIV and ID Observations

Paul E. Sax, MD
Why, Even with Depressing Predictions About Flu Vaccine Effectiveness, We Should Still Recommend and Get It
Each year, the print and broadcast media round up a bunch of experts on influenza and ask them to predict the severity of the upcoming flu season.

Most of the time their responses are noncommittal — predicting how bad the flu season will be year to year is tricky business, akin to picking stocks, making 12-month weather forecasts in an almanac, or naming the winner of the World Series during spring training.

Kevin MD
Make a difference by being a vaccine insister
William Schaffner, MD |

December 5, 2017

When a patient is diagnosed with a chronic disease, like diabetes or hypertension, physicians don’t merely suggest medications to lower blood sugar or blood pressure – they insist that patients take medications to protect their health. However, the recommendation to get an annual influenza (flu) shot to prevent flu is often not as emphatic. Research has shown that patients are much more likely to get a flu shot when it ...

Seasonal Flu - In The News

Canada

Early flu cases could be harbinger of a bad season: B.C. expert
By The Canadian Press, Vancouver Sun
The influenza season in Canada is shaping up to be a potentially nasty one, with a mixed bag of viruses already circulating in much of the country, say infectious diseases experts.

A mother got the flu from her children — and was dead two days later

Dec 7, 2017
According to the CDC, more than 6,000 people have tested positive for the flu so far this year, more than double the number of people infected at this time last year.

Seasonal Flu - Journal Updates

Infectious Disease Clinics - December 2017 Volume 31, Issue 4, Pages 757–766

Influenza in Older Adults

Influenza viruses cause significant morbidity and mortality in older adults. Prevention and treatment are critical for the reduction of morbidity and mortality in this population, but there are several challenges in the diagnosis, treatment, and prevention of influenza infection and its complications in older adults. This article will describe influenza, its epidemiology, clinical presentation, diagnostic modalities, treatment, and current prevention techniques. Despite the identification of influenza early in the last century, much is still not known about how to protect older adults from influenza infection and its complications. Current treatment and prevention strategies are imperfect, particularly in older frail adults.

New England Journal Of Medicine
Chasing Seasonal Influenza — The Need for a Universal Influenza Vaccine
November 29, 2017
(DOI: 10.1056/NEJMp1714916)
As clinicians in the United States prepare for the start of another influenza season, experts have been watching the Southern Hemisphere winter for hints of what might be in store for us in the North. Reports from Australia have caused mounting concern, with record-high numbers of laboratory-confirmed influenza notifications and outbreaks and higher-than-average numbers of hospitalizations and deaths.1 The number of notifications reached 215,280 by mid-October, far exceeding the 59,022 cases reported during the 2009 H1N1 influenza pandemic, according to the Australian Government Department of Health. Influenza A (H3N2) viruses predominated, and the preliminary estimate of vaccine effectiveness against influenza A (H3N2) was only 10%. The implications for the Northern Hemisphere are not clear, but it is of note that the vaccine for this upcoming season has the same composition as that used in the Southern Hemisphere. As we prepare for a potentially severe influenza season, we must consider whether our current vaccines can be improved and whether longer-term, transformative vaccine approaches are needed to minimize influenza-related morbidity and mortality.

Newsletters

Weekly Bull
Read The Latest Issue: Weekly Bull

HCV Advocate
December Newsletter

Highlights
The Liver Meeting by Alan Franciscus:
HCV screening rates among baby boomers
A study on a marker that could lead to a condition called multiple myeloma
Part B of the Co-Star study abut reinfections rates among people who inject drugs
Identification of new subtypes and a new HCV genotype
Adherence rates to treatment and the effect of being cured of hepatitis C
Long-term follow-up on people with no or minimal fibrosis who were cured of hepatitis C – what is their disease progression and liver cancer rates?

The Liver Meeting by Lucinda Porter:
Curing hepatitis C (HCV) and reducing liver cancer
Curing HCV and improvements in quality of life among people with hepatitis C
Increase in liver cancer in patients without cirrhosis
Fatty Liver and heart disease
Men who have sex with men and acute HCV
Mislabeling of herbs and dietary supplements
Parkinson’s disease and hepatitis C medications
HCV treatment and the risk of heart disease
HCV positive livers transplanted to HCV negative recipients

National Viral Hepatitis Roundtable
NVHR Newsletter

The New York City Hepatitis C Task Force
Hep Free NYC Newsletters

Hep Magazine 
Hep Winter 2017 - Special Issue

Highlights
Improving Long-Term Quality of Life
People who beat hepatitis C virus (HCV) see their health-related quality of life (HRQL) improve—and not just in the short term.

Beating Hep C Improves Diabetic Outcomes
People with type 2 diabetes and hepatitis C virus (HCV) who cure the virus tend to improve their blood sugar levels.

Adapting Risky Behaviors Is Vital
Among people with HCV, unhealthy behaviors such as smoking contribute as much to their higher risk of death as the virus itself.

Hepatitis C May Hasten Menopause, Lower Fertility 

Hepatitis C virus (HCV) may compromise women’s reproductive capacity. Earlier treatment of the virus may help mitigate such related risks.

GI & Hepatology

October Newsletter

British Liver Trust
All Newsletters

British Liver Trust - In The News

UK Liver Disease Burden: The Crisis We Can’t Afford
A new report published today in the Lancet warns that the UK liver disease burden is continuing to rise, blighting the poorest groups and lowering economic productivity. Experts argue insufficient measures are being taken to control the main lifestyle risk factors driving this burden of largely preventable disease, namely alcohol consumption, obesity and viral hepatitis.

The Week Magazine
How San Francisco is waging war on hepatitis C

December 6, 2017

Andrew Joseph

Before the development of the latest hepatitis C drugs, which are remarkably effective at curing the disease, the notion of eradication would have been implausible. That is no longer the case. But the virus is now being fueled by drug use, hitting patients who are the hardest to reach and have the least access to care and the pricey medications.

NIH News in Health

NIH News In Health Newsletter

Until next time
Tina

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